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Seamise fires water at high pressure to hit foes from a distance. If a foe manages to get close, it instead swings the anchor it covers at them. Touching a Seamise can result in infection due to the poisonous film that covers its body.

The soul of seaweed adrift in the waves became reborn as this Pokémon. The poisonous barbs all over its body are highly valued as ingredients for making traditional herbal medicine.